We study the groupoid C*-algebra associated to the equivalence relation induced by a quotient map on a locally compact Hausdorff space. This C*-algebra is always a Fell algebra, and if the quotient space is Hausdorff, it is a continuous-trace algebra. We show that the C*-algebra of a locally compact, Hausdorff and principal groupoid is a Fell algebra if and only if the groupoid is one of these relations, extending a theorem of Archbold and Somerset about étale groupoids. The C*-algebras of these relations are, up to Morita equivalence, precisely the Fell algebras with trivial Dixmier-Douady invariant as recently defined by an Huef, Kumjian and Sims. We use twisted groupoid algebras to provide examples of Fell algebras with nontrivial Dixmier-Douady invariant.